Penile intraepithelial neoplasia is a rare precancerous disease of the outer skin layer epidermis of the penis. Zoons balanitis, penile intraepithelial neoplasiacarcinoma in situ erythroplasia of queyrat eq, squamous cell cancer of the penis, malignant melanoma of the penis and rarely basal cell cancer of the penis. Squamous cell carcinoma in situ on the penile mucosa or transitional surfaces is also known as erythroplasia of queyrat. Erythroplasia of queyrat treated with topical 5fluorouracil ncbi. Pathology outlines penile intraepithelial neoplasia pein. Erythroplasia of queyrat is a carcinoma in situthat mainly occurs on the glans penis. Circumcision at an early age is thought to prevent its development. Other names for penile intraepithelial neoplasia include. The journal of cutaneous diseases including syphilis, new york, 1912, 30. Erythroplasia of queyrat is a carcinoma in situ that mainly occurs on the glans penis.
Pdf a case of erythroplasia of queyrat treated with imiquimod 5. Erythroplasia of queyrat uf health, university of florida. The photos of erythroplasia of queyrat below are not recommended for people with a weak psyche. The differential diagnosis of erythroplasia of queyrat may at times be difficult. Reportofa successfullytreatedpatient with topical 5fluorouracil. Clinically, the differential diagnosis of erythroplasia of queyrat includes. Abnormal cells are found on the surface of the skin of the penis. May 29, 2012 differential diagnosis included balanitis example. Clinically, erythroplasia of queyrat appears as red velvety moist smooth plaques and is most common in uncircumcised men over age 40. Tarnovsky2 described it originally in 1891, and in 1893, fournieranddarier3recognizeditas a condition limited to the penis.
Erythroplasia of queyrat definition of erythroplasia of. Squamous cell carcinoma is the secondmost common cancer of the skin after basalcell carcinoma but more common than melanoma. Ulcerated andor papillary lesions usually showed microscopic evidence of erythroplasia of queyrat with squamous cell carcinoma. Erythroplasia of queyrat is an early form of skin cancer found on the penis. Posthectomy approach of erythroplasia of queyrat longdom. Squamous cell cancer in situ can occur on any part of the body. A case of erythroplasia of queyrat treated with imiquimod 5%. Selected cases of eq have been treated successfully using 5fluorouracil. Erythroplasia of queyrat is a squamous cell carcinoma in situ of the glans penis. Bowens disease is a more general term to denote a squamous cell carcinoma in situ.
This term is used only when the cancer occurs on the penis. Nov 30, 2009 erythroplasia of queyrat is a carcinoma in situ that mainly occurs on the glans penis. There are several noninvasive treatment options for erythroplasia of queyrat such as photodynamic therapy, cryosurgery and applying various kinds of topical agents. Treatment of erythroplasia of queyrat often involves removal or destruction of the lesion. This gave rise to the term erythoplasia of queyrat. The proximal peripheral margins of the lesion also involve the corona, sulcus, and prepuce afip neg. Erythroplasia of queyrat is a carcinoma in situ on the glans presenting in the form of.
Erythroplasia of queyrat eq is a rare in situ squamous cell carcinoma scc of the glans penis, which typically appears as one or more wellmarginated. Erythroplasia of queyrat is a premalignant disease affecting the epithelium of the glans penis. Erythroplasia of queyrat wessex centre for plastic and. A study of 2 cases of chronic atypical proliferation. The topic erythroplasia of queyrat you are seeking is a synonym, or alternative name, or is closely related to the medical condition squamous cell carcinoma in situ of penis. Erythroplasia of queyrat deirdre mary fanning, hugh flood department of urology, midwestern regional hospital, dooradoyle, limerick, co. Depending upon the context, this term may refer specifically to carcinoma in situ of the glans penis or vulva appearing as a red patch, or may be used as a synonym of erythroplasia on other mucous membrane or transitional sites. Also, mohs micrographic surgery has been used in the treatment of erythroplasia of queyrat. Erythroplasia of queyrat eq is a carcinoma in situ of the mucosal surface of the penis. Limerick, ireland abstract a 58yearold caucasian male presented to the urology clinic reporting an approximate oneyear history of a persistent irritating, slowly progressive, glans penis redness. Pdf erythroplasia of queyrat treated with topical 5.
Squamous cell carcinoma in situ on the penile mucosa or. Sulzberger and satenstein4 firstreportedeqtobea precancerous. Erythroplasia of queyrat is a squamouscell carcinoma in situ of the glans penis head of the penis or inner prepuce foreskin in males, and the vulvae in females. Tarnovsky originally described erythroplasia of queyrat in 1891, but it was queyrat who coined the term erythroplasia in 1911. The main symptoms are a red rash and irritation on the tip of the penis. Erythroplasia of queyrat has a higher tendency to become invasive in comparison to non genital squamous cell cancer in situ. Erythroplasia of queyrat multimedia encyclopedia health. We describe the case of a 68 years old patient, with clinical and histological diagnosis of erythroplasia of queyrat. Aug 07, 2016 31 bowens disease and erythroplasia of queyrat thomas d. A case of erythroplasia of queyrat treated with imiquimod. Poor hygiene and local irritation, as well as coinfection with hpv8 and hpv16, are potential risk factors. Squamous cell cancer accounts for more than 95% of cases of penile cancer. It presents as a smooth raised reddish area that may or may not be painful. Erythroplasiaofqueyrat treatment with topicallyadministered fluorouracil ltc detlef k.
It usually is not aggressive but can become locally invasive, and it is advisable for a man who might have this condition to receive prompt treatment. The course ofinvolution ofthe lesion andthe pretreatment and posttreatment biopsy specimensare. I think it is a good idea to move this stub article entirely to wider topic erythroplasia. The glans is the predominant location of this lesion, and its nonspecific presentation a sharply defined red patch or plaque, may often lead to a misdiagnosis as one of many mucosal dermatoses. Erythroplasia of queyrat information mount sinai new york. The disorder is rare and comprises less than 1% of malignancies that affect males. Erythroplasia of queyrat is a carcinoma in situ of the mucosa and the transitional epithelia. Cincinnati erythroplasia is a malignant dyskeratosis of unknown etiology, first described. Erythroplasia of queyrat is a particular type of bowens disease that can arise on the glans or prepuce in males. Erythroplasia of queyrat an overview sciencedirect topics. A case of erythroplasia of queyrat successfully treated with combination carbon dioxide laser vaporization and surgery. Nov 07, 2019 erythroplasia of queyrat eq is an in situ squamous cell carcinoma of the penis.
Goette,mc,usa,washington,dc erythroplasia of queyrat in a 72year\xreq\ old patientwas successfullytreated with 5% fluorouracil cream topically in four weeks without any discomfort. Sunlight exposure and immunosuppression are risk factors for scc of the skin, with chronic sun exposure being the strongest environmental risk factor. In 1933, sulzberger and satenstein recognized erythroplasia of queyrat as a form of carcinoma in situ. The condition is typically found in men who have not had the foreskin of the penis surgically removed circumcision. Erythroplasia of queyrat is a term used to describe a rare premalignant lesion of penile in situ squamous cell carcinoma. Erythroplasia of queyrat bowen disease of the glans penis. The condition is most often seen in men who have not been circumcised. Erythroplasia of queyrat eq is an in situ squamous cell carcinoma of the penis.
Erythroplasia of queyrat treated with topical 5fluorouracil scielo. Observations from 100 men with erythroplasia of queyrat eq indicate that the disease is a. We wish you a cure and never get sick of this disease. Basal cell carcinoma of the penis is usually located along the penile shaft. Erythroplasia of queyrat eq appearing as a shiny, erythematous, slightly raised, velvety plaque, and involving the mucosa of the glans penis. Lookingbill and marks principles of dermatology 4th ed. Penile squamous intraepithelial lesion sil low and high grade has been used to establish similarities with cervical sil but penile precancerous lesions are actually more similar to vulvar lesions than to cervical lesions. The term erythroplasia was coined by louis queyrat to describe a precancerous red lesion of the penis. Erythroplasia of queyrat treated with 5% imiquimod cream. Squamous cell carcinoma in situ of penis is a malignant condition affecting the skin or mucosal membranes of the penis.
Erythroplasia of queyrat treated with topical methyl aminolevulinate photodynamic therapy. Although the disease bears queyrats name, paget in i874. Given the size and location of the lesion, preventing the surgical option, we performed the treatment with co2 laser. A clinical diagnosis of erythroplasia of queyrat was established and the test for hpv revealed an association with subtype 16 which excluded other benign inflammatory conditions. It mainly occurs in uncircumcised males, over the age of 40. Erythroplasia of queyrat was originally described by tarnovsky in 1891 and later appreciated as a penile disease by fournier and darier in 1893. Erythroplasia of queyrat is a clinical expression of carcinoma in situ of the penis. It resembles bowens disease and therefore the terms are frequently equated. Department of dermatology, seoul national university college of medicine, seoul, korea imiquimod is a new immunomodulating agent with antitumor and antiviral properties that has been shown to be clin.
Nov 07, 2019 yamaguchi y, hata h, imafuku k, kitamura s, shimizu h. Erythroplasia of queyrat stands for a precancerous lesion, a carcinoma in situ evolving through an epidermoid carcinoma in the. Eq erythroplasia of queyrat manifests itself by single or multiple asymptomatic papules or plaques on the glans penis, or periurethrally, predominantly in. Methods employed include cryotherapy, laser ablation, and surgical excision. There are several noninvasive treatment options for erythroplasia of queyrat. Positive results were obtained after 4 weeks of topical application of 5% imiquimod cream, once daily, 5 times a week.
A premalignant condition morphologically characterised by the presence of the characteristic pagets cells in the intraepithelial tissue of the penis. Malignant dyskeratosis, erythroplasia of queyrat type report of a case william e. Erythroplasia of queyrat is a rare in situ carcinoma of the uncircumcised man and its treatment depends on the extent and location of the lesion. Bowens disease and erythroplasia of queyrat plastic. Erythroplasia of queyrat was ac cepted as an entity after queyrats exhaustiveinvestigationin 1911. Erythroplasia of queyrat epq is a squamous cell carcinoma in situ sccis of the glans penis. May 01, 2020 erythroplasia of queyrat is a type of skin cancer of the penis, seen most commonly in men who are not circumcised. The lesions are well defined, infiltrated areas with shiny, red, velvety surfaces which may be moist or dry, slightly elevated or flat.